An idea to help for quests from hell.
For my need, i have coded a Loot scoring and Turn ready notifier.
It's a bit complicated to code... need to analyse full stuff by type/slot on all toons, i use a personal plugin (finditem query) and other one for the data exchange between Eq instances.
So you can see a small graphical result.
This examines what you have and what you need (quest, stuff, class, unique item and class priority), it returned a score. If your score is equal to 1, you need only this loot to finish the quest.